Side Chain-Dependent Binding of Antitumor Indoloquinoxaline Derivatives to DNA: Comparative Spectroscopic and Viscometric Measurements.
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چکیده
منابع مشابه
Side chain-dependent binding of antitumor indoloquinoxaline derivatives to DNA: comparative spectroscopic and viscometric measurements.
NCA0424 (1) and its side chain positional isomer, NCA0465 (2), are indoloquinoxaline derivatives with potent antitumor activity. To investigate the effect of side chain position for binding with DNA, the interactions of 2 with various B-form DNAs were studied by spectroscopic (circular dichroism (CD), fluorescence and UV) and viscosity measurements and were compared with those of 1. The binding...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2001
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.49.44